Also, if the content was written on separate sheets of vellum before being bound (which I agree it probably was), then the question as to whether the author foresaw the quire ordering and made the opening page distinct from the closing pages. Page one is the introduction to a subject, but page 8 (on the same sheet) would be the conclusion - unless the text is supposed to be read on separate sheets - Read page one, then page 8, then page 2 - then page 7?
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